Journal of Inorganic Materials ›› 2023, Vol. 38 ›› Issue (1): 43-54.DOI: 10.15541/jim20220578

• Topical Section: Anti-epidemic Biomaterials (Contributing Editor: YANG Yong) • Previous Articles     Next Articles

Nanozyme: a New Approach for Anti-microbial Infections

WU Xuetong1,2(), ZHANG Ruofei2, YAN Xiyun2, FAN Kelong2()   

  1. 1. Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China
    2. Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
  • Received:2022-09-29 Revised:2022-11-09 Published:2022-12-09 Online:2022-12-09
  • Contact: FAN Kelong, professor. E-mail: fankelong@ibp.ac.cn
  • About author:WU Xuetong (2000-), female, PhD candidate. E-mail: wuxuetong21@mails.ucas.ac.cn
  • Supported by:
    CAS Interdisciplinary Innovation Team(JCTD-2020-08);Youth Innovation Promotion Association of Chinese Academy of Sciences(2019093)

Abstract:

Bacteria and viruses always posed a threat to human health. Most impressively, SARS-CoV-2 has raged around the world for almost three years, causing huge loss to human health. Facing increasing challenges of drug-resistance and poor treatment efficacy, new solutions are urgently needed to combat pathogenic microorganisms. Recently, nanozymes with intrinsic enzyme-like activities emerged as a promising new type of “antibiotics”. Nanozymes exhibit superior antibacterial and antiviral activities under physiological conditions by efficiently catalyzing generation of a large number of reactive oxygen species. Moreover, enhanced therapeutic effects are achieved in nanozyme-based therapy aided by the unique physicochemical properties of nanomaterials such as photothermal and photodynamic effects. This paper reviews the latest research progress in the field of anti-microbial nanozymes, systematically summarizes and analyzes the principles of nanozymes in the treatment of bacteria and viruses from a mechanistic point of view. An outlook on the future direction and the challenges of new anti-microbial infection nanomaterials are proposed to provide inspiration for developing next generation anti-microbial nanozymes.

Key words: nanozyme, anti-microbial, catalyze, antibacterial, antivirus, review

CLC Number: