2D Nanomaterials from Group VA Single-element: Research Progress in Biomedical Fields

doi:10.15541/jim20220089

Abstract

Abstract:

With the continuous deepening of research on nanomaterials, it has been applied in a wide range of technical fields, and has great potential to support new discoveries in basic sciences. Among them, nanomaterials composed of single elements are of particular interest because they are tractable and readily available in synthesis. Two-dimensional (2D) nanomaterials from Group VA single-element (including black phosphorus, arsenene) have broad application prospects in biological applications such as bioimaging, drug delivery, and diagnostic therapy due to their excellent physical, chemical, electronic, and optical properties. This review summarizes the general properties, synthesis, and modification methods of group VA single-element 2D nanomaterials, and then focuses on their various biomedical applications. Finally, challenges and future prospects of these nanomaterials in the field of biomedicine are discussed.

Key words: VA group elements, nanomaterials, two-dimensional materials, biomedical applications, review

CLC Number:

TB34

LEI Weiyan, WANG Yue, WU Shiran, SHI Dongxin, SHEN Yi, LI Fengfeng. 2D Nanomaterials from Group VA Single-element: Research Progress in Biomedical Fields[J]. Journal of Inorganic Materials, 2022, 37(11): 1181-1191.

Figures/Tables 9

Fig. 1 Mechanism of black phosphorus killing tumor cells[18] The color figure can be obtained from online edition

Fig. 2 Structure of black phosphorus[44] 1 Å=0.1 nm; The color figures can be obtained from online edition

Fig. 3 Schematic illustration of black phosphorus (BP) field effect transistor (FET) biosensor for IgG detection[62] The color figure can be obtained from online edition

Fig. 4 Synthesis method and mechanism of PEGylated black phosphorus nanosheets (BP NSs)[11] The color figure can be obtained from online edition

Fig. 5 Schematic illustration of the degradation process of the PLGAylated black phosphorus quantum dots (BPQDs/PLGA) nanospheres in the physiological environment[52] The color figure can be obtained from online edition

Fig. 6 Top and side views of the atomic structures of grey arsenic (a) and black arsenic (b)[64]

Fig. 7 Schematic illustration of the preparation of PEGylated arsenic nanodots (AsNDs@PEG) and their application to normal and cancer cells[67] The color figure can be obtained from online edition

Fig. 8 Photothermal effects of PEG-modified antimonene quantum dots (a) Infrared images of tumor-bearing mice under different treatments. (G1: saline; G2: NIR only; G3: PEG-modified antimonene quantum dots; G4: PEG-modified antimonene quantum dots + NIR (808 nm, 1 W·cm-2)); (b) Temperature changes at the tumor site; (c) Relative tumor volume; (d) Representative images of tumors harvested at 14 d[68]The color figures can be obtained from online edition

Fig. 9 Schematic illustration of synthetic procedure of 2D multifunctional bismuthene and followed surface modification with bovine serum albumin (BSA), and underlying biomedical applications in multimodal photoacoustic imaging (PAI)/computed tomography (CT) imaging guided photonic cancer treatment (synergistic Photothermal Therapy (PTT) and Photodynamic Therapy (PDT))[70] The color figure can be obtained from online edition

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