Bioactivity and Mechanical Stability of Hydroxyapatite Ceramicsunder Micro-vibration Environment

doi:10.15541/jim20180240

Abstract

Abstract:

This study investigated the bioactivity and mechanical stability of hydroxyapatite (HA) ceramics under micro-vibration stress environment (MVS), and explored influence of physiological stress environment on osteoinductivity of HA ceramics. Results of scanning electron microscopy (SEM) and calcium ion release showed that MVS was beneficial for calcium ion re-deposition and bone-like apatite layer formation in HA with high micro-porosity ((29±1.2)%, (26.4±0.3)%, respectively), while calcium ion release of HA materials with a lower micro-porosity ((10.6±0.8)%) was promoted. Protein adsorption results displayed that 40 Hz MVS promoted while 60 Hz MVS significantly inhibited HA protein adsorption behavior. The compression tests demonstrated that stress environment of MVS did not affect the mechanical stability of the HA scaffolds. Our results suggested that stress environment is an important factor affecting the bioactivity and osteoinductivity of HA ceramics.

Key words: micro-vibration, hydroxyapatite, bioactivity, mechanical properties

CLC Number:

R318
TQ174

Jin-Jie WU, Yan LI, Ren-Chu WEI, Jian-Xin WANG, Shu-Xin QU, Jie WENG, Wei ZHI. Bioactivity and Mechanical Stability of Hydroxyapatite Ceramicsunder Micro-vibration Environment[J]. Journal of Inorganic Materials, 2019, 34(4): 417-424.

Figures/Tables 7

Fig. 1 XRD patterns of HA10, HA20, HA35 and porous HA scaffolds

Fig. 2 SEM images of HA materials (a) HA10; (b) HA20; (c) HA35; (d) HA porous scaffold; (d1) Partial magnification of porous scaffoldss

Fig. 3 Calcium release concentration of HA slices with different mass fraction (HA10, HA20, HA35) under 40 Hz and 60 Hz frequency and static state incubation environment at d3, d7 and d14 (* represents statistical difference, P<0.05)

Fig. 4 Protein adsorption concentration of HA discs with different mass fraction (HA10, HA20, HA35) under 40 Hz and 60 Hz frequency and static state incubation environment at d1 and d3 (* represents statistical difference, P<0.05)

Fig. 5 SEM results of HA ceramic discs with different mass fraction soaked in SBF solution for 3 and 7 d (a) Static state; (b) 40 Hz; (c) 60 Hz; 1: HA10-at d 3; 2: HA10- at d 7; 3: HA20- at d 3; 4: HA20- at d 7; 5: HA35- at d 3; 6: HA35- at d 7

Fig. 6 EDS spectra of HA materials after 7 d in SBF solution (a) Static state; (b) 40 Hz; (c) 60 Hz; 1: HA10-at d 7; 2: HA20-at d 7; 3: HA35-at d 7

Fig. 7 Compressive strength of HA porous scaffold under static state, 40 and 60 Hz vibration frequency incubated for 7 and 14 d

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