Preparation of Superparamagnetic Gold Nanocomposites with Different Diameters and Their Imaging and Therapy Applications

doi:10.15541/jim20150077

Abstract

Abstract:

Superparamagnetic gold nanocomposites (SGNs), which have great potential in magnetic resonance imaging (MRI) and photothermal therapy (PT) on cancer, have been successfully synthesized via the in-situ reduction and the following seed-mediated growth route. It is found that the dimension of SGNs could be facilely tuned by changing the encapsulation amount of Fe₃O₄/tetrahydrofuran solution, and SGNs with diameters of 100, 150 and 200 nm were thus obtained. The as-synthesized SGNs present regularly spherical morphology, narrow size distributions and monodispersity in aqueous solutions. It is revealed that SGNs modified with SH-PEG are capable for simultaneous MRI and photothermal therapy. Especially, SGNs with average diameter of 150 nm exhibit the strongest absorption capacity and highest photothermal conversion efficiency with 808 nm laser. The temperatures in vitro and in vivo were increased by 37 ℃ and 25 ℃, respectively. Therefore, it is hopeful that tumor can be imaged well and killed efficiently under laser irradiation after intratumoral injection of such a kind of nanocomposites.

Key words: Fe3O4, gold shell, nanocomposites, photothermal therapy, MRI

CLC Number:

TQ174

ZHAI Yun-Gang, DONG Wen-Jie, GAO Yong-Ping, NIU De-Chao, CHEN Jian-Zhuang, GU Jin-Lou, LI Yong-Sheng, SHI Jian-Lin. Preparation of Superparamagnetic Gold Nanocomposites with Different Diameters and Their Imaging and Therapy Applications[J]. Journal of Inorganic Materials, 2015, 30(9): 950-956.

Figures/Tables 7

Fig. 1 Dynamic size distributions of the SGNs at different stages (a) and different diameters (b)

Fig. 2 SEM images of Au-SSCNs and SGNs with different diameters (a) Au-SSCNs-1; (b) Au-SSCNs-2; (c) Au-SSCNs-3; (d) SGNs-1; (e) SGNs-2; (f) SGNs-3

Fig. 3 TEM images of Au-SSCNs and SGNs with different diameters (a) Au-SSCNs-1; (b) Au-SSCNs-2; (c) Au-SSCNs-3; (d) SGNs-1; (e) SGNs-2; (f) SGNs-3

Fig. 4 UV-Vis spectra and digital photographs of SGNs with different diameters (a) and temperature change of SGNs-PEG with different diameters under irradiation time of 808 nm laser (b)

Fig. 5 MDA-MB-435 cell viability cultured with SGNs-PEG at different Au concentrations under 808 nm laser irradiation (a) and plots of inverse transverse relaxation time (1/T2) vs Fe concentration (b)

Fig. 6 Infrared thermal images of saline and SGNs-PEG intratumoral injected tumor-bearing mices without (pre) and with (post) laser irradiation

Fig. 7 In vivo T2-weighted MRIs of tumor-bearing mice before (pre) and after (post) intratumoral administration of SGNs-PEG of different diameters

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