Preparation and Characterization of Nano-hydroxyapatite/PLGA Composites with Novel Surface-modified Nano-hydroxyapatite

doi:10.3724/SP.J.1077.2013.12502

Journal of Inorganic Materials ›› 2013, Vol. 28 ›› Issue (7): 751-756.DOI: 10.3724/SP.J.1077.2013.12502

• Research Paper • Previous Articles Next Articles

Preparation and Characterization of Nano-hydroxyapatite/PLGA Composites with Novel Surface-modified Nano-hydroxyapatite

JIANG Li-Xin^{1, 2}, JIANG Liu-Yun¹, MA Chi^{1, 2}, HAN Chong-Tao^{1, 2}, XU Li-Juan^{1, 2}, XIONG Cheng-Dong¹

(1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China; 2. Graduated University of the Chinese Academy of Sciences, Beijing 100049, China)

Received:2012-08-17 Revised:2012-10-18 Published:2013-07-20 Online:2013-06-19
About author:JIANG Li-Xin. E-mail: jlx198765@126.com
Supported by:
Talent Training Project of West Light Foundation of Chinese Academy of Science; National Natural Science Foundation of China (31000440)

Abstract

Abstract: Nano-hydroxyapatite (n-HA) was modified by a new method of combining silane coupling reagent (KH550) with surface-grafting L-lactide LLA. Then, the surface-modified n-HA (g-n-HA) was introduced into poly(lactic-co-glycolic acid) (PLGA) to prepare a series of g-n-HA/PLGA composites with the concentration of 3wt%, 10wt%, 20wt% and 30wt%. The properties of the g-n-HA/PLGA composites were characterized and compared with PLGA and n-HA/PLGA composites. The results show that n-HA is successfully modified by KH550 and L-LA. The g-n-HA particles could disperse more uniformly in PLGA matrix and promote PLGA to crystallize. The obtained g-n-HA/PLGA composites has better mechanical properties than those of n-HA/PLGA composites with the same amount of n-HA. Moreover, the bending and tensile strength of g-n-HA/PLGA composite containing 10wt% g-n-HA are 14.4% and 11.3% which is higher than that of pure PLGA, respectively. Therefore, the g-n-HA/PLGA composite is promising for bone fracture internal fixation material in future.

Key words: nano-hydroxyapatite (n-HA), surface modification, composite, PLGA

CLC Number:

R318

JIANG Li-Xin, JIANG Liu-Yun, MA Chi, HAN Chong-Tao, XU Li-Juan, XIONG Cheng-Dong. Preparation and Characterization of Nano-hydroxyapatite/PLGA Composites with Novel Surface-modified Nano-hydroxyapatite[J]. Journal of Inorganic Materials, 2013, 28(7): 751-756.

References

[1] Fiedler T, Belova I V, Murch GE, et al. Tailoring elastic properties of PLGA/TiO2 biomaterials. Computational Materials Science, 2012, 61(8): 283–286.

[2] Ebrahimian-Hosseinabadi M, Ashrafizadeh F, Etemadifar M, et al. Evaluating and modeling the mechanical properties of the prepared PLGA/nano-BCP composite scaffolds for bone tissue engineering. Journal of Materials Science & Technology, 2011, 27(12): 1105–1112.

[3] Orlovskii V P, Komlev V S, Barinov S M. Hydroxyapatite and hydroxyapatite-based ceramics. Inorganic Materials, 2002, 38(10): 973–984.

[4] Yang C, Cheng K, Weng W, et al. OTS-modified HA and its toughening effect on PLLA/HA porous composite. Journal of Materials Science: Materials in Medicine, 2009, 20(3): 667–672.

[5] Liu Q, de Wijn JR, Bakker D, et al. Polyacids as bonding agents in hydroxyapatite polyester-ether (polyactiveTM 30/70) composites. Journal of Materials Science: Materials in Medicine, 1998, 9(1): 23–30.

[6] LIAO Jian-Guo, WANG Xue-Jiang, ZUO Yi, et al. Surface modification of nano-hydroxyapatite with silane agent. Journal of Inorganic Materials, 2008, 23(1): 145–149.

[7] Borum-Nicholas L, Wilson Jr OC. Surface modification of hydroxyapatite. Part I. Dodecyl alcohol. Biomaterials, 2003, 24(21): 3671–3679.

[8] Cui Y, Liu Y, Cui Y, et al. The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with l-lactic acid oligomer for bone repair. Acta Biomaterialia, 2009, 5(7): 2680–2692.

[9] 于婷, 刘娅, 王宇, 等(YU Ting, et al). 改性纳米羟基磷灰石/ PLGA复合材料的制备及生物活性. 高等学校化学学报(Chem. J. Chinese U.), 2009, 30(7): 1439–1444.

[10] Jiang L Y, Li Y B, Zhang L, et al. Preparation and properties of a novel bone repair composite: nano-hydroxyapatite/chitosan/ carboxymethyl cellulose. Journal of Materials Science-Materials in Medicine, 2008, 19(3): 981–987.

[11] Hong Z, Qiu X, Sun J, et al. Grafting polymerization of l-lactide on the surface of hydroxyapatite nano-crystals. Polymer, 2004, 45(19): 6699–6706.

[12] Li J, Lu X L, Zheng Y F. Effect of surface modified hydroxyapatite on the tensile property improvement of HA/PLA composite. Applied Surface Science, 2008, 255(2): 494–497.

[13] Tonsuaadu K, Peld M, Leskela T, et al. A themroanalytical study of synthetic carbonate-conatining apatites. Thermochimica Acta, 1995, 256(1): 55–65.

[14] Wei J, Liu A, Chen L, et al. The surface modification of hydroxyapatite nanoparticles by the ring opening polymerization of γ-benzyl-L-glutamate N-carboxyanhydride. Macromolecular Bioscience, 2009, 9(7): 631–638.

[15] Hong Z K, Zhang P B, He C L, et al. Nano-composite of poly (L-lactide) and surface grafted hydroxyapatite: mechanical properties and biocompatibility. Biomaterials, 2005, 26(32): 6296–6304.

[16] LI Hai-Yan, TAN Ye-Qiang, ZHANG Lu, et al. Bio-filler from mussel shell: preparation and its effects on polypropylene composites properties. Journal of Inorganic Materials, 2012, 27(9): 977–983.

Preparation and Characterization of Nano-hydroxyapatite/PLGA Composites with Novel Surface-modified Nano-hydroxyapatite

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