Regulation of Potassium Aminocarboxylates on Calcium Oxalate Crystal Growth and Its Relationship with Molecular Structure

doi:10.3724/SP.J.1077.2010.01185

Abstract

Abstract: The effect of potassium aminocarboxylates on crystallization of calcium oxalate (CaOxa) was investigated in silica gel system by means of scanning electron microscopy and X-ray diffraction. These aminocarboxylates included potassium aminoacetate (KGLY), dipotassium glycoletherdiaminotetraacetate (K₂EGTA), dipotassium aminotriacetate (K₂NTA), dipotassium diethylenetriaminepenteacetate (K₂DTPA), dipotassium ethylene diamine tetraacetate (K₂EDTA) and dipotassium cyclohexanediamine tetraacetate (K₂CDTA). All these aminocarboxylates could induce the formation of calcium oxalate dihydrate (COD), inhibit the aggregation of calcium oxalate monohydrate (COM) and decrease the specific surface area of COM aggregates. The ability to induce COD formation follows the order: K₂DTPA (55wt%) > K₂EDTA ≈K₂CDTA (50wt%) > K₂NTA (43wt%) >> K₂EGTA (4wt%) > KGLY (2wt%), and the ability to inhibit COM aggregation follows the sequence: K₂DTPA>K₂NTA > K₂CDTA≈K₂EDTA > K₂EGTA > KGLY. These results are discussed in terms of their molecular structure, relative content of carboxylic groups, spatial location of carboxyl groups in aminocarboxylates, and their coordination capacity and modes with Ca²⁺ ions. It is proved that K₂NTA and K₂DTPA can be the potential drugs for preventing the formation of CaOxa stones.

Key words: calcium oxalate, potassium aminocarboxylates, chelators, biomineralization, urinary stone

CLC Number:

O611

YANG Jin, LI Jun-Jun, YUAN Huan-Xin, OUYANG Jian-Ming. Regulation of Potassium Aminocarboxylates on Calcium Oxalate Crystal Growth and Its Relationship with Molecular Structure[J]. Journal of Inorganic Materials, 2010, 25(11): 1185-1190.

References

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