Preparation and Properties of Nano Calcium Deficient Apatite/Poly (ε-caprolactone) Composite Scaffold

doi:10.3724/SP.J.1077.2010.00500

Abstract

Abstract:

Nano calcium deficient hydroxyapatite (cd-HA) and poly(ε-caprolactone) (PCL) composite scaffold with well interconnected and open macropores was prepared by rapidprototyping technique, and its pore size and porosity was controlled. In addition, the characterization of the microstructure of the cdHA/PCL composite scaffold was carried out. The biological properties of the composite scaffold were investigated through cell culture and animal model experiments. The results showed that the hydrophilicity and cell attachment ratio of the composite increased with the increase of cd-HA content in the cd-HA/PCL composite, and the proliferation ratio of the MG63 cells on the composite scaffold was much higher than that on the PCL scaffold. Radiological and histological examinations confirmed that the newly bony tissue formed on the surfaces of the composite scaffold and grew into the pores of the composite scaffolds. The well interconnected macropores in the composite scaffolds might encourage cell proliferation and thus enhance new bone formation in the porous scaffolds. In summary, the results indicates that the cd-HA/PCL composite scaffold with excellent biocompatibility has potential application in tissue engineering.

Key words: calcium deficient hydroxyapatite, nano composite, rapidprototyping, porous scaffold

CLC Number:

TB383

WANG Zhi-Wei, SU Jia-Can, MA Yu-Hai, ZHANG Xin, CAO Lie-Hu, LI Ming. Preparation and Properties of Nano Calcium Deficient Apatite/Poly (ε-caprolactone) Composite Scaffold[J]. Journal of Inorganic Materials, 2010, 25(5): 500-506.

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