Luminescent Properties and Cytotoxicity of CdTe Quantum Dots with Different Stabilizing Agents

doi:10.3724/SP.J.1077.2010.00495

Abstract

Abstract:

CdTe quantum dots (QDs) were prepared in aqueous phase using thioglycolic acid (TGA), L-cysteine(L-Cys), and glutathione (GSH) as stabilizing agents. The luminescent properties of CdTe QDs with different stabilizing agents were studied by using fluorescence spectra. FTIR spectra analysis demonstrates that CdTe QDs are capped with stabilizing agents through the coordination interaction between Cd²⁺ and S. Fluorescence spectra show that CdTe QDs with longer emission wavelength (680nm) can be synthesized more easily when L-Cys or GSH is chosen as stabilizing agents and TGA is proper to prepare highly luminescent QDs because of the effect between Cd2+ and sulfhydryl group. The MTT assay and morphology analysis of U87MG cells suggest that the QDs with different stabilizing agents are all toxic to cells. The cytotoxicity of TGAQDs is higher than that of L-Cys- and GSH- CdTe. The cell viability is only 52.6% when U87MG cells are treated with 20μg/mL of TGA-QDs for 24h.

Key words: stabilizing agents, CdTe, quantum dots, luminescence, cytotoxicity

CLC Number:

O614

LI Zheng-1, 2 , WANG Yong-Xian-1, ZHANG Guo-Xin-1, HAN Yan-Jiang- 1, 2. Luminescent Properties and Cytotoxicity of CdTe Quantum Dots with Different Stabilizing Agents[J]. Journal of Inorganic Materials, 2010, 25(5): 495-499.

References

[1]Wuister S F, Swart I, Driel F V, et al. Highly luminescent water-soluble CdTe quantum dots. Nano Lett., 2003, 3(4): 503-507.
[2]Kapitonov A M, Stupak A P, Gaponenko S V, et al. Luminescence properties of thiol-stabilized CdTe nanocrystals. J. Phys. Chem. B, 1999, 103(46): 10109-10113.
[3]Wang S P, Mamedova N, Kotov N A, et al. Antigen/antibody immunocomplex from CdTe nanoparticle bioconjugates. Nano Lett., 2002, 2(8): 817-822.
[4]陈良冬,李雁,袁宏银,等.量子点在肿瘤研究中的应用. 癌症, 2006, 25(5): 651- 656.
[5]徐万帮,汪勇先,许荣辉,等(XU Wan-Bang, et al). Ⅱ-Ⅵ型量子点的制备、修饰及其生物应用. 无机材料学报(Journal of Inorganic Materials), 2006, 21(5): 322-328.
[6]Gaponik N, Talapin D V, Rogach A L, et al. Thiol-capping of CdTe nanocrystals: An alternative to organometallic synthetic routes. J. Phys. Chem. B, 2002, 106(29): 7177-7185.
[7]唐爱伟, 滕枫, 高银浩,等(TANG Ai-Wei, et al). 水相中CdSe与核／壳CdSe／CdS量子点的制备与发光特性研究. 无机材料学报(Journal of Inorganic Materials), 2006, 21(2): 322-328.
[8]刘明贤, 孙颖, 甘礼华, 等(LIU Ming-Xian, et al).静电自组装制备CdTe量子点纳米薄膜.无机材料学报(Journal of Inorganic Materials), 2008, 23(3): 557-561.
[9]Hoshino A, Fujioka K, Oku T, et al. Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett., 2004, 4(11): 2163-2169.
[10]Guo J, Yang W L, Wang C C. Systematic study of the photoluminescence dependence of thiol-capped CdTe nanocrystals on the reaction conditions. J. Phys. Chem. B, 2005, 109(37): 17467-17473.
[11]Peng X G, Wickham J, Alivisatos A P. Kinetics of Ⅱ-Ⅵ and Ⅲ-Ⅴ colloidal semiconductor nanocrystal growth: “Focusing” of size distributions. J. Am. Chem. Soc., 1998, 120(21): 5343-5344.
[12]侯绍英, 张岭, 吴坤,等. 巯基乙酸对孕酮诱导爪蟾卵母细胞体外成熟过程中MAPK和MPF激酶活性的影响.癌变·畸变·突变, 2008, 20(2): 107-110.

[1]	YANG Yingkang, SHAO Yiqing, LI Bailiang, LÜ Zhiwei, WANG Lulu, WANG Liangjun, CAO Xun, WU Yuning, HUANG Rong, YANG Chang. Enhanced Band-edge Luminescence of CuI Thin Film by Cl-doping [J]. Journal of Inorganic Materials, 2023, 38(6): 687-692.
[2]	WANG Zhiqiang, WU Ji’an, CHEN Kunfeng, XUE Dongfeng. Large-size Er,Yb:YAG Single Crystal: Growth and Performance [J]. Journal of Inorganic Materials, 2023, 38(3): 329-334.
[3]	LIU Qi, ZHU Can, XIE Guizhen, WANG Jun, ZHANG Dongming, SHAO Gangqin. Optical Absorption and Photoluminescence Spectra of Ce-doped SrMgF₄Polycrystalline with Superlattice Structure [J]. Journal of Inorganic Materials, 2022, 37(8): 897-902.
[4]	GUAN Xufeng, LI Guifang, WEI Yunge. Microstructure and Thermal Quenching Characteristics of Na_1-_xM_xCaEu(WO₄)₃ (M=Li, K) Red Phosphor [J]. Journal of Inorganic Materials, 2022, 37(6): 676-682.
[5]	ZHANG Guoqing, QIN Peng, HUANG Fuqiang. Reversible Conversion between Space-confined Lead Ions and Perovskite Nanocrystals for Confidential Information Storage [J]. Journal of Inorganic Materials, 2022, 37(4): 445-451.
[6]	DU Aochen, DU Qiyuan, LIU Xin, YANG Yimin, XIA Chenyang, ZOU Jun, LI Jiang. Ce:YAG Transparent Ceramics Enabling High Luminous Efficacy for High-power LEDs/LDs [J]. Journal of Inorganic Materials, 2021, 36(8): 883-892.
[7]	ZHANG Cong, LI Yurou, SHAO Kang, LIN Jing, WANG Kai, PAN Zaifa. Luminescence Property of the Multicolor Persistent Luminescence Materials for Dynamic Anti-counterfeiting Applications [J]. Journal of Inorganic Materials, 2021, 36(12): 1256-1262.
[8]	TIAN Jianjian, MA Xia, WANG Min, YAO Heliang, HUA Zile, ZHANG Lingxia. Sn Quantum Dots for Electrocatalytic Reduction of CO₂ to HCOOH [J]. Journal of Inorganic Materials, 2021, 36(12): 1337-1342.
[9]	SHU Mengyang, LU Jialin, ZHANG Zhijie, SHEN Tao, XU Jiayue. CsPbBr₃ Perovskite Quantum Dots/Ultrathin C₃N₄ Nanosheet 0D/2D Composite: Enhanced Stability and Photocatalytic Activity [J]. Journal of Inorganic Materials, 2021, 36(11): 1217-1222.
[10]	PENG Yuehong,REN Weizhou,QIU Jianbei,HAN Jin,YANG Zhengwen,SONG Zhiguo. Upconversion Luminescence and Temperature Sensing Properties of Layered BiOCl: Er³⁺ under 1550 nm Excitation [J]. Journal of Inorganic Materials, 2020, 35(8): 902-908.
[11]	ZHANG Zhijie,HUANG Hairui,CHENG Kun,GUO Shaoke. High Efficient Carbon Quantum Dots/BiOCl Nanocomposite for Photocatalytic Pollutant Degradation [J]. Journal of Inorganic Materials, 2020, 35(4): 491-496.
[12]	CHEN Ting, XU Yanqiao, JIANG Weihui, XIE Zhixiang, WANG Lianjun, JIANG Wan. Ionic Liquid Assisted Microwave Synthesis of Cu-In-Zn-S/ZnS Quantum Dots and Their Application in White LED [J]. Journal of Inorganic Materials, 2020, 35(4): 439-446.
[13]	WANG Meng-Hui,SHEN Hui,TIAN Tian,XIAN Qin,XU Jia-Yue,JIN Min,JIA Run-Ping. Preparation and Tunable Luminescence of Eu Doped KNN Ceramics [J]. Journal of Inorganic Materials, 2020, 35(2): 236-242.
[14]	CHEN Lei, CHEN Lanhua, ZHANG Yugang, XIE Jian, DIWU Juan. A Layered Uranyl Coordination Polymer with UV Detection Sensitivity, Stability, and Reusability [J]. Journal of Inorganic Materials, 2020, 35(12): 1391-1397.
[15]	WANG Kai, YAN Li-Ping, SHAO Kang, ZHANG Cong, PAN Zai-Fa. Near-infrared Afterglow Enhancement and Trap Distribution Analysis of Silicon-chromium Co-doped Persistent Luminescence Materials Zn₁₊_xGa_2-2_xSi_xO₄:Cr³⁺ [J]. Journal of Inorganic Materials, 2019, 34(9): 983-990.