Preparation and Drug Release Properties of Nanostructured CaCO3 Porous Hollow Microspheres

doi:10.3724/SP.J.1077.2009.00166

Abstract

Abstract: CaCO₃ nanostructured porous hollow microspheres were synthesized using CaCl₂, Na₂CO₃, SDS in aqueous solution at room temperature. The products were characterized by X-ray powder diffraction (XRD), transmission electron microscope (TEM) and scanning electron microscope (SEM). The drug loading and release properties of CaCO₃ nanostructured porous hollow microspheres were investigated in artificial gastric juice (pH＝1.2) and simulated intestinal fluid (pH＝7.4). Ibuprofen (IBU) was used as a model drug. The drug delivery system constructed by IBU/CaCO₃ porous hollow microspheres exhibits high drug loading capacity and good drug release property. The IBU loading amount reaches 195mg/g and its release time can last for more than 53h. In comparison, the IBU loading amount reaches 130mg/g in thermally treated CaCO₃ hollow microspheres in which SDS is eliminated, and the drug release time can reach 40h when IBU release percentage is 100%. The produced CaCO₃ nanostructured porous hollow microspheres have the potential application in the sustained drug delivery.

Key words: CaCO₃, nanostructure, hollow sphere, drug delivery

CLC Number:

R318

LI Liang,ZHU Ying-Jie,CAO Shao-Wen,MA Ming-Yan. Preparation and Drug Release Properties of Nanostructured CaCO₃ Porous Hollow Microspheres[J]. Journal of Inorganic Materials, DOI: 10.3724/SP.J.1077.2009.00166.

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Preparation and Drug Release Properties of Nanostructured CaCO₃ Porous Hollow Microspheres

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