Abstract: The effects of the contents of different regulators including D-sorbital, mannose, galactose, glucose, and fructors on the growth of
hydroxyapaptite crystal seeds were studied, and the crystal seeds obtained were then applied to the in-situ reinforcement of calcium phosphate
cement. The experimental results show that the discrepancies of the surface energy and structure of the crystal of different orientations lead to
different growth rates, and this is the thermodynamic foundation of its in situ reinforcement. The compressive strength of the hardening
body is up to 76.1 MPa, the diamentral tensile strength is up to 24.5 MPa.

Key words: hydroxyapatite, crystal seed, calcium phosphate cement, in-situ reinforcement