VA族单元素二维纳米材料在生物医用领域的研究进展

doi:10.15541/jim20220089

无机材料学报 ›› 2022, Vol. 37 ›› Issue (11): 1181-1191.DOI: 10.15541/jim20220089

VA族单元素二维纳米材料在生物医用领域的研究进展

雷伟岩¹(), 王岳², 武世然², 石东新², 沈毅¹^,²(), 李锋锋²

1.华北理工大学矿业工程学院，唐山 063210
2.华北理工大学材料科学与工程学院, 河北省无机非金属材料重点实验室, 唐山 063210

收稿日期:2022-02-23 修回日期:2022-03-17 出版日期:2022-05-09 网络出版日期:2022-05-09
通讯作者: 沈毅, 教授. E-mail: shenyilzt@163.com
作者简介:雷伟岩(1992-), 男, 博士研究生. E-mail: leiphd@163.com
基金资助:
国家自然科学基金(51772099)

2D Nanomaterials from Group VA Single-element: Research Progress in Biomedical Fields

LEI Weiyan¹(), WANG Yue², WU Shiran², SHI Dongxin², SHEN Yi¹^,²(), LI Fengfeng²

1. School of Mining Engineering, North China University of Science and Technology, Tangshan 063210, China
2. Hebei Provincial Key Laboratory of Inorganic Nonmetallic Materials, School of Materials Science and Engineering, North China University of Science and Technology, Tangshan 063210, China

Received:2022-02-23 Revised:2022-03-17 Published:2022-05-09 Online:2022-05-09
Contact: SHEN Yi, professor. E-mail: shenyilzt@163.com
About author:LEI Weiyan (1992-), male, PhD candidate. E-mail: leiphd@163.com
Supported by:
National Natural Science Foundation of China(51772099)

摘要/Abstract

摘要：

纳米材料在不同技术领域均有广泛应用, 且在解决基础科学新发现上拥有巨大潜力。其中单元素构成的纳米材料因合成容易、制备简单而倍受关注, 尤其VA族二维单元素纳米材料(包括黑磷、砷烯等)的物理、化学、电子和光学特性优异, 在生物成像、药物递送和诊断治疗等生物医学领域应用前景广阔。本文总结了VA族二维单元素纳米材料的一般特性、合成和修饰方法, 重点介绍了其面向各种生物医学应用的纳米平台的研究进展, 最后, 讨论了其在生物医学领域所面临的挑战并展望了未来的发展方向。

关键词: VA族元素, 纳米材料, 二维材料, 生物应用, 综述

Abstract:

With the continuous deepening of research on nanomaterials, it has been applied in a wide range of technical fields, and has great potential to support new discoveries in basic sciences. Among them, nanomaterials composed of single elements are of particular interest because they are tractable and readily available in synthesis. Two-dimensional (2D) nanomaterials from Group VA single-element (including black phosphorus, arsenene) have broad application prospects in biological applications such as bioimaging, drug delivery, and diagnostic therapy due to their excellent physical, chemical, electronic, and optical properties. This review summarizes the general properties, synthesis, and modification methods of group VA single-element 2D nanomaterials, and then focuses on their various biomedical applications. Finally, challenges and future prospects of these nanomaterials in the field of biomedicine are discussed.

Key words: VA group elements, nanomaterials, two-dimensional materials, biomedical applications, review

中图分类号:

TB34

雷伟岩, 王岳, 武世然, 石东新, 沈毅, 李锋锋. VA族单元素二维纳米材料在生物医用领域的研究进展[J]. 无机材料学报, 2022, 37(11): 1181-1191.

LEI Weiyan, WANG Yue, WU Shiran, SHI Dongxin, SHEN Yi, LI Fengfeng. 2D Nanomaterials from Group VA Single-element: Research Progress in Biomedical Fields[J]. Journal of Inorganic Materials, 2022, 37(11): 1181-1191.

图/表 9

图1 黑磷杀伤肿瘤细胞的机制[18]

Fig. 1 Mechanism of black phosphorus killing tumor cells[18] The color figure can be obtained from online edition

图2 黑磷的结构[44]

Fig. 2 Structure of black phosphorus[44] 1 Å=0.1 nm; The color figures can be obtained from online edition

图3 用于IgG检测的黑磷FET生物传感器示意图[62]

Fig. 3 Schematic illustration of black phosphorus (BP) field effect transistor (FET) biosensor for IgG detection[62] The color figure can be obtained from online edition

图4 PEG化黑磷纳米片的合成方法及作用机理[11]

Fig. 4 Synthesis method and mechanism of PEGylated black phosphorus nanosheets (BP NSs)[11] The color figure can be obtained from online edition

图5 BPQDs/PLGA纳米球在生理环境中的降解过程示意图[52]

Fig. 5 Schematic illustration of the degradation process of the PLGAylated black phosphorus quantum dots (BPQDs/PLGA) nanospheres in the physiological environment[52] The color figure can be obtained from online edition

图6 灰砷(a)和黑砷(b)原子结构的俯视图和侧视图[64]

Fig. 6 Top and side views of the atomic structures of grey arsenic (a) and black arsenic (b)[64]

图7 AsNDs@PEG的制备以及应用于正常细胞和癌细胞的示意图[67]

Fig. 7 Schematic illustration of the preparation of PEGylated arsenic nanodots (AsNDs@PEG) and their application to normal and cancer cells[67] The color figure can be obtained from online edition

图8 PEG修饰的锑烯量子点的光热治疗效果

Fig. 8 Photothermal effects of PEG-modified antimonene quantum dots (a) Infrared images of tumor-bearing mice under different treatments. (G1: saline; G2: NIR only; G3: PEG-modified antimonene quantum dots; G4: PEG-modified antimonene quantum dots + NIR (808 nm, 1 W·cm-2)); (b) Temperature changes at the tumor site; (c) Relative tumor volume; (d) Representative images of tumors harvested at 14 d[68]The color figures can be obtained from online edition

图9 二维多功能铋纳米片的合成、BSA表面修饰以及多模式 PA/CT 成像引导的光子癌症治疗(协同PTT和PDT)示意图[70]

Fig. 9 Schematic illustration of synthetic procedure of 2D multifunctional bismuthene and followed surface modification with bovine serum albumin (BSA), and underlying biomedical applications in multimodal photoacoustic imaging (PAI)/computed tomography (CT) imaging guided photonic cancer treatment (synergistic Photothermal Therapy (PTT) and Photodynamic Therapy (PDT))[70] The color figure can be obtained from online edition

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VA族单元素二维纳米材料在生物医用领域的研究进展

2D Nanomaterials from Group VA Single-element: Research Progress in Biomedical Fields

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