介孔生物活性玻璃/脱钙骨复合支架的制备及性能研究

doi:10.3724/SP.J.1077.2011.01068

无机材料学报 ›› 2011, Vol. 26 ›› Issue (10): 1068-1072.DOI: 10.3724/SP.J.1077.2011.01068

介孔生物活性玻璃/脱钙骨复合支架的制备及性能研究

薛士壮¹, 朱海霖¹, 陈建勇¹, 冯新星^1,2, 常江²

(1. 浙江理工大学先进纺织材料与制备技术教育部重点实验室, 材料与纺织学院, 杭州 310018; 2. 中国科学院上海硅酸盐研究所高性能陶瓷和超微结构国家重点实验室, 上海 200050)

收稿日期:2010-11-23 修回日期:2011-01-12 出版日期:2011-10-20 网络出版日期:2011-09-20
作者简介:薛士壮(1984-), 男, 硕士研究生. E-mail: shizhuang_xue@126.com
基金资助:
国家自然科学基金(50973096, 50903073,31070867); 浙江省科技厅公益项目(2010C31038)

Preparation and Properties of Mesoporous Bioactive Glass / Demineralized Bone Composite Scaffolds

XUE Shi-Zhuang¹, ZHU Hai-Lin¹, CHEN Jian-Yong¹, FENG Xin-Xing^1,2, CHANG Jiang²

(1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textiles; Zhejiang Sci-Tech University, Hangzhou 310018, China; 2. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China)

Received:2010-11-23 Revised:2011-01-12 Published:2011-10-20 Online:2011-09-20
Supported by:
National Natural Science Foundation of China(50973096, 50903073,31070867); Commonweal Project of Science and Technology Department of Zhejiang Province(2010C31038)

摘要/Abstract

摘要： 将介孔生物活性玻璃(MBG)与脱钙骨(DB)复合, 利用浸渍法制备出MBG/DB复合支架材料. 采用红外光谱(FTIR), 扫描电镜(SEM), X射线衍射(XRD), 电子万能材料试验机等方法对牛松质骨(CB)、DB、MBG/DB复合支架进行表征. 结果表明, CB经浸酸处理后制备的DB, 孔径大小在200~600μm范围内, 孔隙率约为71%, 抗压性能比CB明显降低(1.10±0.31)MPa, 而采用浸渍法制备的复合支架, 孔隙率降为40%左右, 而压缩强度明显提高(8.49± 2.14)MPa. 体外生物活性测试表明: 复合支架具有良好的生物活性.

关键词: 介孔生物活性玻璃, 脱钙骨, 复合支架, 生物活性

Abstract: The composite scaffolds (MBG/DB) were prepared successfully through immersing the mesoporous bioactive glass powders into the demineralized bones. The bovine cancellous bone, demineralized bone, composite scaffold were investigated and characterized by FTIR, SEM, XRD and universal electromechanical testing machine. The results show that the compressive strength of the demineralized bones is about (1.10±0.31)MPa, the porosity is about 71% and the pore size is in the range from 200 to 600μm. However, the porosity and the compressive strength of the composite scaffolds are decreased to 40% and increase markedly to (8.49±2.14)MPa, respectively. Meanwhile, the composite scaffolds show good bioactivity in vitro.

Key words: mesoporous bioactive glass, demineralized bone, composite scaffold, bioactivity

中图分类号:

R318

薛士壮, 朱海霖, 陈建勇, 冯新星, 常江. 介孔生物活性玻璃/脱钙骨复合支架的制备及性能研究[J]. 无机材料学报, 2011, 26(10): 1068-1072.

XUE Shi-Zhuang, ZHU Hai-Lin, CHEN Jian-Yong, FENG Xin-Xing, CHANG Jiang. Preparation and Properties of Mesoporous Bioactive Glass / Demineralized Bone Composite Scaffolds[J]. Journal of Inorganic Materials, 2011, 26(10): 1068-1072.

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介孔生物活性玻璃/脱钙骨复合支架的制备及性能研究

Preparation and Properties of Mesoporous Bioactive Glass / Demineralized Bone Composite Scaffolds

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