TiO2纳米管表面蛋白质-羟基磷灰石复合涂层及其结合强度

doi:10.3724/SP.J.1077.2011.00987

无机材料学报 ›› 2011, Vol. 26 ›› Issue (9): 987-992.DOI: 10.3724/SP.J.1077.2011.00987

TiO₂纳米管表面蛋白质-羟基磷灰石复合涂层及其结合强度

于榕, 冯波, 汪建新, 鲁雄, 屈树新, 翁杰

(西南交通大学材料先进技术教育部重点实验室材料科学与工程学院, 成都 610031)

收稿日期:2010-10-26 修回日期:2010-12-22 出版日期:2011-09-20 网络出版日期:2011-08-19
作者简介:于榕(1984-), 女, 硕士研究生. E-mail: 08091003@163.com
基金资助:
国家自然科学基金(50871093), 教育部高等学校全国优秀博士学位论文作者专项资金(200554)

Protein-hydroxyapatite Composite Coatings on TiO₂ Nanotube Layers and Bond Strength to Substrate

YU Rong, FENG Bo, WANG Jian-Xin, LU Xiong, QU Shu-Xin,WENG Jie

(Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China)

Received:2010-10-26 Revised:2010-12-22 Published:2011-09-20 Online:2011-08-19
Supported by:
National Natural Science Foundation of China (50871093); Foundation for the Author of National Excellent Doctoral Dissertation of China (200554)

摘要/Abstract

摘要： 采用阳极氧化法在钛表面制备不同管径的TiO₂纳米管, 450℃热处理后经牛血清白蛋白(BSA)与钙磷的共沉积得到载有BSA的羟基磷灰石(HA)涂层. 经检测发现, 170nm管径的TiO₂表面比100和50nm管径的表面具备更好的矿化能力, HA的形成能力随管径的增大而提高. 大管径表面得到的涂层结合强度高于小管径的, 可达16.95MPa. 经过真空预矿化的试样, 涂层结合强度明显高于未经过预矿化的试样, 且HA涂层生长速率加快. BSA与磷酸钙在真空预矿化后共沉积到氧化钛纳米管表面, 短时期内形成BSA-HA涂层, 是在钛基生物材料表面制备生物活性涂层的有效方法.

关键词: TiO₂纳米管, 牛血清白蛋白, 磷灰石涂层, 结合强度

Abstract: TiO₂ nanotubes on titanium with different diameters were prepared by anodic oxidation after heat-treated at 450℃. Hydroxyapatite (HA) coatings containing bovine serum albumin (BSA) were produced on the nanostructured surface through biomimetic co-deposition. The TiO₂ nanotube layers with 170nm diameter has a better mineralization ability compared that with diameter of 100nm and 50nm, And the HA formation ability is enhanced with increase of the diameters. The bonding strength of the coating to the nanotube layers with large diameter is higher than that with small diameter, and the maximal strength can reach 16.95MPa. Moreover, the pre-mineralization in vacuum significantly enhances the bonding strength, and increases growth rate of the coating. The BSA-HA coating with high bonding strength can fastly form on TiO₂ nanotube layers by pre-mineralization in vacuum and then biomimetic co-deposition, which would be a promised method for preparing titanium-based bioacitive coatings.

Key words: TiO₂ nanotubes, bovine serum albumin, apatite coating, bonding strength

中图分类号:

TG146

于榕, 冯波, 汪建新, 鲁雄, 屈树新, 翁杰. TiO₂纳米管表面蛋白质-羟基磷灰石复合涂层及其结合强度[J]. 无机材料学报, 2011, 26(9): 987-992.

YU Rong, FENG Bo, WANG Jian-Xin, LU Xiong, QU Shu-Xin,WENG Jie. Protein-hydroxyapatite Composite Coatings on TiO₂ Nanotube Layers and Bond Strength to Substrate[J]. Journal of Inorganic Materials, 2011, 26(9): 987-992.

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TiO₂纳米管表面蛋白质-羟基磷灰石复合涂层及其结合强度

Protein-hydroxyapatite Composite Coatings on TiO₂ Nanotube Layers and Bond Strength to Substrate

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