复合磷酸盐多孔生物陶瓷的制备及体外细胞相容性

doi:10.3724/SP.J.1077.2011.00759

无机材料学报 ›› 2011, Vol. 26 ›› Issue (7): 759-764.DOI: 10.3724/SP.J.1077.2011.00759

复合磷酸盐多孔生物陶瓷的制备及体外细胞相容性

刘斌¹, 董寅生², 林萍华², 张俊³, 苏静¹

(1. 南京信息工程大学数理学院, 南京 210044; 2. 东南大学材料科学与工程学院, 南京 211189; 3. 东南大学医学院, 南京 210009)

收稿日期:2010-09-15 修回日期:2010-11-15 出版日期:2011-07-20 网络出版日期:2011-06-20
作者简介:刘斌(1977-), 男, 博士. E-mail: liubinnuist@nuist.edu.cn
基金资助:
国家自然科学基金(51002079); 南京信息工程大学科研基金(20080291)

Preparation of Polyphosphate Porous Bioceramics and in vitro Cytocompatibility

LIU Bin¹, DONG Yin-Sheng², LIN Ping-Hua², ZHANG Jun³, SU Jing¹

(1. College of Math & Physics, Nanjing University of Information & Technology, Nanjing 210044, China; 2. School of Materials Science and Engineering, Southeast University, Nanjing 211189, China; 3. Medical College, Southeast University, Nanjing 210009, China)

Received:2010-09-15 Revised:2010-11-15 Published:2011-07-20 Online:2011-06-20
Supported by:
National Natural Science Foundation of China (51002079); Scientific Research Foundation of Nanjing University of Information & Technology (20080291)

摘要/Abstract

摘要： 以Al₂O₃-MgO-P₂O₅磷酸盐为粘结剂, 采用有机泡沫浸渍工艺制备了多孔陶瓷, 采用扫描电镜(SEM)、X射线衍射(XRD)、排水法和压缩实验等表征了多孔陶瓷的孔隙形貌、相组成、孔隙率和力学性能, 并通过体外细胞实验研究了其细胞相容性. 结果表明, Al₂O₃-MgO-P₂O₅磷酸盐的加入不仅可以使浆料能够均匀地涂覆在泡沫体上, 也促进了陶瓷的烧结. 得到的多孔陶瓷具有相互连通、分布均匀的孔隙结构(大孔孔径在100~500μm, 还有约为3μm微孔), 平均孔隙率为85.9%±1.6%, 平均压缩强度为(1.04±0.15)MPa; 多孔陶瓷虽然是一种由HA、β-Ca₂P₂O₇和少量含Mg、Al的物相组成的复合磷酸盐陶瓷, 但在体外实验中没有表现出明显的细胞毒性, 并能促进细胞快速增殖与分化, 表明该多孔陶瓷具有良好的细胞亲和性和相容性.

关键词: 复合磷酸盐, 多孔陶瓷, Al₂O₃-MgO-P₂O₅, 细胞相容性

Abstract: The porous ceramics were prepared by the foam impregnation technology using Al₂O₃-MgO-P₂O₅ as binder. Porous morphology, crystalline phase, porosity, and mechanical property were investigated by using scaning electron microscope (SEM), X-ray diffraction (XRD), Archimedes drainage method, and compression tests. It was found that Al₂O₃-MgO-P₂O₅phosphate promoted the sintering of ceramics, and improved coating of ceramic slurry over the foams uniformly. The obtained ceramics have connective, uniform pore structures with macro-pores of about 100-500μm in diameter and micro-pores of about 3μm in diameter. Their average porosity and compressive strength were 85.9%±1.6% and (1.04±0.15) MPa respectively. Although sintered porous ceramics were polyphosphates composed of HA, β-Ca₂P₂O₇ and a few phases including Al and Mg. They had no cytotoxicity and provoked the proliferation and differentiation of marrow stromal stem cells in vitro. Thus it can be concluded that this kind of porous ceramics has good cellular affinity and cytocompatibility.

Key words: polyphosphates, porous ceramics, Al₂O₃-MgO-P₂O₅, cytocompatibility

中图分类号:

TQ174
R318

刘斌, 董寅生, 林萍华, 张俊, 苏静. 复合磷酸盐多孔生物陶瓷的制备及体外细胞相容性[J]. 无机材料学报, 2011, 26(7): 759-764.

LIU Bin, DONG Yin-Sheng, LIN Ping-Hua, ZHANG Jun, SU Jing. Preparation of Polyphosphate Porous Bioceramics and in vitro Cytocompatibility[J]. Journal of Inorganic Materials, 2011, 26(7): 759-764.

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复合磷酸盐多孔生物陶瓷的制备及体外细胞相容性

Preparation of Polyphosphate Porous Bioceramics and in vitro Cytocompatibility

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