具有良好贯通性的颗粒造孔支架的制备及表征

doi:10.3724/SP.J.1077.2011.00017

无机材料学报 ›› 2011, Vol. 26 ›› Issue (1): 17-21.DOI: 10.3724/SP.J.1077.2011.00017

具有良好贯通性的颗粒造孔支架的制备及表征

郭来阳¹, 张靖微¹, 赵婧¹, 汪建新¹, 翁杰¹, 张聪²

1. 材料先进技术教育部重点实验室, 西南交通大学材料科学与工程学院, 成都610031; 2. 解放军第452医院, 成都610021

收稿日期:2010-02-09 修回日期:2010-04-28 出版日期:2011-01-20 网络出版日期:2010-12-23
作者简介:郭来阳(1983-),男，硕士研究生.E-mail: gaozai@163.com
基金资助:
国家自然科学基金重点项目(30870630); 教育部高等学校博士学科专项科研基金(20070613062); 四川省科技计划项目(2008Jy0062)

Preparation andCharacterization of Porous Scaffolds with Favourable Interpore Connectivity

GUOLai-Yang¹, ZHANG Jing-Wei¹, ZHAO Jing¹, WANGJian-Xin¹, WENG Jie¹, ZHANG Cong²

1. KeyLaboratory of Advanced Technologies of Materials, Ministry of Education, Schoolof Materials Science and Engineering, Southwest Jiaotong University, Chengdu610031, China; 2. 452nd Hospital of Chinese PLA, Chengdu 610021, China

Received:2010-02-09 Revised:2010-04-28 Published:2011-01-20 Online:2010-12-23
Supported by:
National Nature Science Foundation ofChina(30870630); Specialized Research Fund for the Doctoral Program of HigherEducation(20070613062); Science and Technology Research Foundation of SichuanProvince(2008Jy0062)

摘要/Abstract

摘要： 支架孔隙贯通性的研究一直是多孔生物陶瓷的研究重点之一.采用石蜡球作为造孔剂, 在常规的颗粒造孔法制备多孔陶瓷支架的基础上,通过二甲苯处理以便在石蜡球间形成桥联结构, 以扩大颗粒间的接触面积,从而提高多孔陶瓷支架的孔隙贯通性. 借助扫描电镜(SEM)观察陶瓷支架的多孔结构,评价二甲苯处理石蜡球对陶瓷支架孔隙贯通性的改善效果; 采用密度法测定了陶瓷支架的孔隙率并计算其收缩率,并用成骨细胞评价陶瓷支架的细胞相容性. 结果表明,通过二甲苯的处理, 不仅改善了陶瓷支架孔隙的贯通性,而且提高了其孔隙率, 但孔隙率对陶瓷支架的收缩率无明显影响.细胞培养实验显示成骨细胞可进入多孔陶瓷支架内部, 并在材料表面正常生长,贯通性好的多孔陶瓷支架可为成骨细胞生长提供更充分的空间.

关键词: 多孔支架, 颗粒造孔, 贯通性, 桥联结构

Abstract: The pore interconnectivity isa key factor for the application of porous bioceramics as bone tissue engineeringscaffolds. Packed wax spheres were treated with dimethyl benzene and acted as theporogen for the preparation of porous ceramic scaffolds, in order to increasethe inter-sphere connectivity. The morphology, porosity, shrinkage, and thecompressive strength of the obtained ceramic scaffolds were analyzed. The cellcompatibility of the scaffolds was evaluated with Sprague-Dawley (SD) osteoblasts.The results showed that the pore interconnectivity and volumetric porosity weresignificantly increased by the dimethyl benzene treatment. Scaffolds with differentporosities had similar shrinkage. Osteoblasts migrated deeply into the centerof the porous ceramic scaffold through the interconnected pores and got normalactivity. Porous scaffolds with better interpore connectivity could provid morespace for the proliferation of osteoblasts.

Key words: porousscaffolds, particulate-leaching, interpore connectivity, bridging

中图分类号:

R318
TQ174

郭来阳, 张靖微, 赵婧, 汪建新, 翁杰, 张聪. 具有良好贯通性的颗粒造孔支架的制备及表征[J]. 无机材料学报, 2011, 26(1): 17-21.

GUOLai-Yang, ZHANG Jing-Wei, ZHAO Jing, WANGJian-Xin, WENG Jie, ZHANG Cong. Preparation andCharacterization of Porous Scaffolds with Favourable Interpore Connectivity[J]. Journal of Inorganic Materials, 2011, 26(1): 17-21.

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具有良好贯通性的颗粒造孔支架的制备及表征

Preparation andCharacterization of Porous Scaffolds with Favourable Interpore Connectivity

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