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无机材料学报

无机材料学报

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碳酸钙纳米结构多孔空心微球的制备及其药物缓释性能研究

李 亮， 朱英杰， 曹少文， 马明燕
  

  1. 中国科学院上海硅酸盐研究所 高性能陶瓷和超微结构国家重点实验室，上海 200050
  • 收稿日期:2008-05-04 修回日期:2008-06-03 出版日期:2009-01-20 网络出版日期:2009-01-20

Preparation and Drug Release Properties of Nanostructured CaCO3 Porous Hollow Microspheres

LI Liang, ZHU Ying-Jie, CAO Shao-Wen, MA Ming-Yan   

  1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
  • Received:2008-05-04 Revised:2008-06-03 Published:2009-01-20 Online:2009-01-20

PDF (PC)

2368

被引次数

127 | 14

摘要： 以CaCl2和Na2CO3为反应物，十二烷基硫酸钠（SDS）为表面活性剂，在室温水溶液中制备了纳米结构碳酸钙空心球.用TEM和SEM对其进行形貌观察发现，所制备的碳酸钙空心球的球壁由纳米粒子组成，具有多孔形貌特征.分别在模拟胃液（pH＝1.2）以及模拟肠液（pH＝7.4）中对制备的纳米结构碳酸钙空心球进行了药物装载和缓释性能的研究，选用的药物为布洛芬（IBU）.研究结果表明,IBU/CaCO3多孔空心微球药物传输体系具有较高的药物装载量和良好的药物缓释性能，纳米结构碳酸钙空心球中IBU的装载量可以达到195mg/g，且连续释药时间能持续53h以上；除去表面活性剂后，载体中IBU的装载量可达到130mg/g，药物释放率为100%时，持续释药时间可达到40h.纳米结构碳酸钙多孔空心球作为药物载体材料在药物缓释体系中具有潜在的应用前景.

关键词: 碳酸钙, 纳米结构, 多孔空心微球, 药物传输

Abstract: CaCO3 nanostructured porous hollow microspheres were synthesized using CaCl2, Na2CO3, SDS in aqueous solution at room temperature. The products were characterized by X-ray powder diffraction (XRD), transmission electron microscope (TEM) and scanning electron microscope (SEM). The drug loading and release properties of CaCO3 nanostructured porous hollow microspheres were investigated in artificial gastric juice (pH＝1.2) and simulated intestinal fluid (pH＝7.4). Ibuprofen (IBU) was used as a model drug. The drug delivery system constructed by IBU/CaCO3 porous hollow microspheres exhibits high drug loading capacity and good drug release property. The IBU loading amount reaches 195mg/g and its release time can last for more than 53h. In comparison, the IBU loading amount reaches 130mg/g in thermally treated CaCO3 hollow microspheres in which SDS is eliminated, and the drug release time can reach 40h when IBU release percentage is 100%. The produced CaCO3 nanostructured porous hollow microspheres have the potential application in the sustained drug delivery.

Key words: CaCO3, nanostructure, hollow sphere, drug delivery

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