致密磷酸钙陶瓷在动态SBF中类骨磷灰石层形成研究

无机材料学报

致密磷酸钙陶瓷在动态SBF中类骨磷灰石层形成研究

段友容; 王朝元; 陈继镛; 张兴栋

四川大学生物材料工程研究中心成都 610064

收稿日期:2001-04-27 修回日期:2001-10-11 出版日期:2002-05-20 网络出版日期:2002-05-20

Bone-like Apatite Formation on Calcium Phosphate Dense Ceramicsin Dynamic SBF

DUAN You-Rong; WANG Chao-Yuan; CHEN Ji-Yong; ZHANG Xing-Dong

Engineering Research Center in Biomaterials; Sichuan University; Chengdu 610064; China

Received:2001-04-27 Revised:2001-10-11 Published:2002-05-20 Online:2002-05-20

摘要/Abstract

摘要： 磷酸钙陶瓷植入体内后其表面类骨磷灰石层的形成是诱导成骨的先决条件．本实验在模拟体液(ｓｉｍｕｌａｔｅｄｂｏｄｙｆｌｕｉｄ,ＳＢＦ)以人体骨骼肌组织内体液的正常生理流率(２ｍＬ/１００ｍＬ·ｍｉｎ)和偏离正常生理流率流动的动态条件下,研究在动态ＳＢＦ中影响致密磷酸钙陶瓷表面类骨磷灰石层形成的因素．结果表明:在生理流率条件下,材料的粗糙表面有利于类骨磷灰石的形成,加大ＳＢＦ中Ｃａ^２＋、ＨＰＯ_４^２－离子浓度,类骨磷灰石层的形成速度加快．比起通常使用的静态浸泡试验,ＳＢＦ以生理流率流动的动态试验能够更好地模拟类骨磷灰石生长的体内环境．动态ＳＢＦ对了解类骨磷灰石形成,进而了解磷酸钙陶瓷在体内诱导成骨机理是十分有用的．

关键词: 致密磷酸钙陶瓷, 动态SBF, 类骨磷灰石

Abstract: Bone-like apatite formation on the surface of calcium phosphate ceramics has been believed to be the necessary step that new bone grows on the ceramics and
to be relative to the osteoinductivity of the material. The research of the factors effecting bone-like apatite formation is a great help to understanding the mechanism
of osteoinduction. This study was a comparative study of in vitro formation of bone-like apatite on the surface of dense calcium phosphate ceramics with SBF
flowing at different speeds. The results showed that the rough surface was beneficial to the formation of bone-like apatite and the apatite formed faster in 1.5 SBF
than in SBF. Rough surface, namely, larger surface area, increased the dissolution of Ca²⁺, HPO₄^2- and higher concentration of Ca²⁺ and HPO₄^2- ions of SBF
was advantageous to the accumulation of Ca²⁺, HPO4^2-, PO₄^3- near the ceramic surface. Local supersaturating concentration of Ca²⁺, HPO₄^2-, PO₄^3-
near sample surface was critical for nucleation of apatite on the surface of sample.

Key words: dense calcium phosphate ceramics, dynamic SBF, bone-like apatite

中图分类号:

R318

段友容,王朝元,陈继镛,张兴栋. 致密磷酸钙陶瓷在动态SBF中类骨磷灰石层形成研究[J]. 无机材料学报.

DUAN You-Rong,WANG Chao-Yuan,CHEN Ji-Yong,ZHANG Xing-Dong. Bone-like Apatite Formation on Calcium Phosphate Dense Ceramicsin Dynamic SBF[J]. Journal of Inorganic Materials.

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