Damaging Effects of Nanosized TiO2 on Bel-7402 Human Liver Cancer Cell Under Photoinduce

doi:10.3724/SP.J.1077.2006.01467

Abstract

Abstract: The damaging effects of nanosized
TiO₂ on human Bel-7402 liver cancer cell were investigated by means of HE
dye method and MTT colorimetric assay under condition of photoinduce. The
influences of nanosized TiO₂ content, and irradiation time on cancer inhibition were systematically studied, and the inhibition mechanism was primarily discussed. The results show that nanosized TiO₂ exhibits good inhibition effects under appropriate TiO₂ concentration, and the inhibition process obeys first order reaction rule approximately; In addition, activity oxygen produced by nanosized TiO₂ under illumination can react with organicmolecules in and out the cancer cell membrane, so that lead to damage cell structure, result into imbalance of Ca ²⁺ in the cancer cell, and induce microtubule reassembly due to expression changes of microtubule-associated protein-2, which are responsible for the apoptotic and dead cancer cells.

Key words: nanosized TiO2, photoinduced-damage, liver cancer cell, MAP-2

CLC Number:

O643
R735

XIA Chun-Hui,WANG Bai-Qi,WANG Yu,LIU Ya-Qin,XU Guang-You,WU Shan. Damaging Effects of Nanosized TiO₂ on Bel-7402 Human Liver Cancer Cell Under Photoinduce[J]. Journal of Inorganic Materials, DOI: 10.3724/SP.J.1077.2006.01467.

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Damaging Effects of Nanosized TiO₂ on Bel-7402 Human Liver Cancer Cell Under Photoinduce

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