Abstract: A novel porous scaffold of calcium phosphate cement with porosity-controllable, pore size-controllable and morphology-controllable was prepared and cell culture with scaffold was studied, also, the biodegradation of the porous scaffold in SBF was investigated. The results reveal that the compressive strength of the porous bone cement can reach 4MPa, the porosity of the scaffold can reach 70%,
abundant micropores are on the wall of the macroposes and the pores are interconnected with each other, the cultural cell are attached, dispersed and preferentially proliferated on the surface of the scaffolds materials. The biodegradation ratio increases with the increasing of porosity and decreasing of Ca/P ratio of the calcium phosphate cement. The scaffolds not only have good
biocompatibility but also biodegradation. The novel new type of biodegradable Ca-P materials can be used as scaffolds for bone defect repair and tissue engineering.

Key words: porous scaffold, calcium phosphate cement, biodegradation, biocompatibility