表面改性对介孔硅酸钙镁/聚醚醚酮复合材料性能的影响

doi:10.15541/jim20170120

摘要/Abstract

摘要：

实验制备了介孔硅酸钙镁/聚醚醚酮复合骨修复材料, 采用砂纸打磨及喷砂对其表面进行改性。结果表明: 表面改性明显提高了复合材料表面的粗糙度和亲水性(水接触角降低), 喷砂在复合材料表面暴露出大量的介孔硅酸钙镁, 形成了多孔结构, 粗糙度和亲水性提高最大。表面改性复合材料在模拟体液中浸泡7 d后, 表面都形成了大量磷灰石; 表面改性促进了MC3T3-E1细胞在复合材料表面粘附、增殖和分化。喷砂比砂纸打磨更明显地提高了复合材料的生物学性能。

关键词: 介孔硅酸钙镁, 聚醚醚酮, 复合材料, 表面改性, 表面性能

Abstract:

Mesoporous calcium magnesium silicate (m-MCS)/polyetheretherketone (PK) bioactive composites for bone repair were prepared, and the surfaces of composites were modified by sanding and sandblasting treatment. The surface roughness of the composites modified by sandblasting was R_a=4.552 while the surface roughness of the composites modified by sanding were 1.727 and 2.103, which were higher than that of the untreated composites (1.359). In addition, the water contact angle of the composites treated by sandblasting was 54.1° while the water contact angles of the composites modified by sanding were 76.3° and 71.6°, which were higher than that of the untreated composites (81.2°). The results indicated that surface roughness and hydrophilicity of composites were significantly enhanced by sandblasting treatment. Porous surface structure and a large number of mesoporous calcium magnesium silicates were exposed on the composites surfaces after sandblasting treatment, resulted in the maximum surface roughness and hydrophilicity. After immersed in simulated body fluid (SBF) solution for 7 d, massive apatites were formed on the composites surfaces, showing a good bioactivity. The in vitro cell experiments indicated that the surface modified composites could significantly promote adhesion, proliferation and differentiation of MC3T3-E1 cells on the surfaces. Therefore, sandblasting treatment could significantly improve the biological performances of the composites as compared with sanding treatment.

Key words: mesoporous calcium magnesium silicate, polyetheretherketone, composite, surface modification, surface properties

中图分类号:

TB383

施张宇, 李全, 唐颂超, 钱军, 潘泳康, 魏杰. 表面改性对介孔硅酸钙镁/聚醚醚酮复合材料性能的影响[J]. 无机材料学报, 2018, 33(1): 67-74.

SHI Zhang-Yu, LI Quan, TANG Song-Chao, QIAN Jun, PAN Yong-Kang, WEI Jie. Surface Modification on Property of Mesoporous Calcium Magnesium Silicate/Polyetheretherketone Composites[J]. Journal of Inorganic Materials, 2018, 33(1): 67-74.

图/表 9

图1 m-MCS的TEM照片(a)和EDS图谱(b)

Fig. 1 TEM image (a) and EDS spectrum (b) of m-MCS

图2 表面改性复合材料的SEM照片((a) MPC; (b) MPC8, (c) MPC4; (d) MPCsb)和XRD图谱(e)

Fig. 2 SEM images ((a) MPC; (b) MPC8; (c) MPC4; (d) MPCsb) and XRD patterns (e) of the composites after surface modification

图3 表面改性复合材料的激光显微镜2D照片

Fig. 3 Laser microscope 2D images of the surface modified composites^(a) MPC; (b) MPC8; (c) MPC4; (d) MPCsb

图4 表面改性复合材料的激光显微镜3D照片

Fig. 4 Laser microscope 3D images of the surface modified composites^(a) MPC; (b) MPC8; (c) MPC4; (d) MPCsb

表1 表面改性复合材料的表面粗糙度和水接触角

Table 1 Surface roughness and water contact angle of the surface modified composites

Samples	R_a/µm	Water contact angle/(°)
MPC	1.359	81.2
MPC8	1.727	76.3
MPC4	2.103	71.6
MPCsb	4.552	54.1

图5 表面改性复合材料在SBF中浸泡7d的SEM照片^(a) MPC; (b) MPC8; (c) MPC4; (d) MPCsb和MPCsb表面矿化的EDS图谱(e)

Fig. 5 SEM images of the surface modified composites soaked in SBF for 7 d ^(a) MPC; (b) MPC8; (c) MPC4; (d) MPCsb and (e) EDS spectrum of MPCsb

图6 表面改性复合材料在SBF中浸泡不同时间的离子(Ca, P和Si)浓度变化

Fig. 6 Changes of ion (Ca,P and Si) concentrations for the surface modified composites soaked in SBF solution for different periods^(a) MPC; (b) MPC8; (c) MPC4; (d) MPCsb

图7 MC3T3-E1细胞在表面改性复合材料培养72 h的激光共聚焦照片

Fig. 7 CLSM photos of MC3T3-E1 cells cultivated on the surface modified composites for 72 h^(a) MPC; (b) MPC8; (c) MPC4; (d) MPCsb

图8 MC3T3-E1细胞在表面改性复合材料((a) MPC; (b) MPC8; (c) MPC4; (d) MPCsb)培养不同时间的细胞增殖(A)和ALP活性(B)

Fig. 8 Cell proliferation (A) and ALP activity (B) of MC3T3- E1 cells on the surface modified composites ^(a) MPC; (b) MPC8; (c) MPC4; (d) MPCsb for different periods

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