掺锶羟基磷灰石的制备与性能研究

doi:10.3724/SP.J.1077.2011.00049

无机材料学报 ›› 2011, Vol. 26 ›› Issue (1): 49-54.DOI: 10.3724/SP.J.1077.2011.00049 CSTR: 32189.14.SP.J.1077.2011.00049

掺锶羟基磷灰石的制备与性能研究

李志宏, 武继民, 黄姝杰, 关静, 张西正

军事医学科学院卫生装备研究所, 天津 300161

收稿日期:2010-03-20 修回日期:2010-05-29 出版日期:2011-01-20 网络出版日期:2010-12-23
作者简介:李志宏(1977-), 男, 硕士, 助理研究员. E-mail: lizhihong1003@tom.com
基金资助:
天津市自然科学基金(09JCYBJC14100); 国家自然科学基金重点项目(10832012); 军事医学科学院科研创新;重大项目(2008ZD009)

Preparation and Property of Strontium-substitutedHydroxyapatite

LI Zhi-Hong,WU Ji-Min,HUAN Shu-Jie,GUAN Jin,ZHANG Xi-Zheng

Instituteof Medical Equipment, Academy of Military and Medical Sciences, Tianjin 300161, China

Received:2010-03-20 Revised:2010-05-29 Published:2011-01-20 Online:2010-12-23
Supported by:
Nature Science Foundation of Tianjing(09JCYBJC14100); National Nature Science Foundation ofChina (10832012); Scientific Research Project of Academy of Military and Medical Sciences(2008ZD009)

摘要/Abstract

摘要： 掺锶羟基磷灰石的骨缺损修复效果优于羟基磷灰石. 以四水硝酸钙[Ca(NO₃)₂·4H₂O]、磷酸氢二铵[(NH₄)₂HPO₄]、硝酸锶[Sr(NO₃)₂]为原料, 180℃下水热处理8h制得Sr-HA. 通过XRD、FTIR、TEM、EDX和TG/DTA对Sr-HA的晶相、化学组成、形貌和热稳定性进行分析, 并通过细胞培养, MTT比色法对材料的细胞毒性进行评价.结果表明: Sr取代部分Ca进入HA的晶格中. 随着Sr含量的增加, Sr-HA晶粒尺寸呈减小趋势, 热稳定性下降. 掺锶对羟基磷灰石细胞毒性影响较小, 锶磷灰石具有良好的生物相容性.

关键词: 掺锶羟基磷灰石, 合成, 水热法, 细胞毒性

Abstract: The biological HA in the body differs from that of pure HA in stoichiometry,composition, physical properties and mechanical properties, because this HA isparticularly prone to ion substitution. As a cation that can substitute forcalcium in the structure of hydroxyapatite, strontium provokes an increasinginterest because of its beneficial effect on bone formation, and prevention ofbone resorption. Here, strontium-substituted HA powders were prepared by thehydrothermal method at 180℃ for 8 h using Ca(NO₃)₂·4H₂O, (NH₄)₂HPO₄and Sr(NO₃)₂ as reagents. X-ray diffraction, Fouriertransform infrared spectroscope, transmission electron microscope, energy dispersiveX-ray, and thermogravimetric-differential thermal analysis were employed toinvestigate the crystalline phase, chemical composition, morphology, and thermalstability of the Sr-HA. And the cytotoxicity of Sr-HA was analyzed through MTT assay. The results showthat Sr is incorporated into the HA crystal structure and the crystal grainsize of the Sr-HA decreases as the Sr content (under 50wt%) is increased.Moreover, the HA thermal stability decreases. However, there’s no apparentdifference between the pure hydroxyapatite and all of the Sr-HA groups in cytotoxicity,which may have good biocompatibility.

Key words: strontium-substituted hydroxyapatite, synthesis, hydrothermalmethod, cytotoxicity

中图分类号:

李志宏, 武继民, 黄姝杰, 关静, 张西正. 掺锶羟基磷灰石的制备与性能研究[J]. 无机材料学报, 2011, 26(1): 49-54.

LI Zhi-Hong,WU Ji-Min,HUAN Shu-Jie,GUAN Jin,ZHANG Xi-Zheng. Preparation and Property of Strontium-substitutedHydroxyapatite[J]. Journal of Inorganic Materials, 2011, 26(1): 49-54.

参考文献

[1] Shi Donglu. Introduction to Biomaterials. Beijing: Tsinghua UniversityPress. 2006: 16-28.
[2] Blake GM, Fogelman I. Long-term effect of strontium ranelate treatmenton BMD. J. Bone Miner. Res., 2005, 20(11): 1901-1904.
[3] Hott M, Deloffre P, Tsouderos Y, etal. S12911-2 reduces bone loss induced by short-term immobilization inrats. Bone, 2003, 33(1): 115-123.
[4] Compston J. Prevention of vertebral fractures by strontium ranelate inpostmenopausal women with osteoporosis. OsteoporosInt., 2005, 16(suppl 1): 4-6.
[5] Kendler D L. Strontium ranelate—data on vertebral and nonvertebral fractureefﬁcacy and safety: mechanism of action. Curr.Osteoporos Rep., 2006, 4(1): 34-39.
[6] Okaayama S, Akao M, Nakamura S, etal. The mechanical properties and solubility of strontium substitutedhydroxyapatite. Biomed. Mater. Eng.,1991, 1(1): 11-17.
[7] 陈德敏, 傅远飞, 顾国珍, 等. 掺锶羟磷灰石固溶体的制备及离解度测定. 中国生物医学工程学报, 2001, 20(3): 278-280.
[8] 廖大鹏, 周正炎, 顾云峰, 等. 锶磷灰石烧结体修复颌骨缺损的实验研究. 口腔颌面外科杂志,2001, 11(2): 122-137
[9] Donazzon B, Dechambre G, Lacout J. Calcium-strontium hydroxyapatitehydrothermal preparation. Ann. Chim. Sci.Mat.,1998, 23(1/2): 53-56.
[10]张玉梅, 王勤涛, 付涛, 等(ZHANGYu-Mei, et al). 含锶羟基磷灰石的湿法合成与结构稳定性.稀有金属材料与工程(Rare Metal Mat. Eng.), 2004,33(10): 1049-1051
[11]Yokogawa Y, Toriyama M,Kawamoto Y. Preparation of calcium- strontium apatite through mechanochemicalmethod. Chem. Lett.,1996, 289(1): 91-92.
[12]BalamuruganA, Balossier G, Torres P, et al. Sol-Gel synthesis and spectrometric structural evaluation ofstrontium substituted hydroxyapatite. MaterialsScience and Engineering C, 2009, 29(3):1006-1009
[13]李洋, 冉旭, 苟立, 等. 微波合成掺锶羟基磷灰石. 化工进展, 2007, 26(10): 1466-1469
[14]Li ZY, Lam W M, Yang C, et al. Chemical composition, crystal size and lattice structural changesafter incorporation of strontium into biomimetic apatite. <>Biomaterials,2007 (28): 1452-1460
[15]林英光, 杨卓如, 程江. 溶胶-凝胶结合超临界流体干燥法制备纳米掺锶羟基磷灰石的研究. 高校化学工程学报, 2006,21(3): 454-459
[16]Bouyer E, Gitzhofer F, Boulos MI. Morphological study of hydroxyapatite nanocrystal suspension. J. Mater. Sci.: Mater. Med., 2000, 11: 523-531.
[17]Guerra-López J, Pomés R, DellaVé dova C O, et al. Influence ofnickel on hydroxyapatite crystallization. <>J. Raman Spectrosc., 2001, 32(4): 255-261.
[18]郭大刚, 徐可为, 憨勇(GUO Da-Gang, et al). 理想化学配比掺锶羟基磷灰石的热稳定性. 稀有金属材料与工程(Rare Metal Mat. Eng.),2006, 35(3): 379-382.
[19]傅远飞, 陈德敏. 掺锶对羟磷灰石细胞毒性的影响. 功能材料, 2008, 39(4): 645-646.

掺锶羟基磷灰石的制备与性能研究

Preparation and Property of Strontium-substitutedHydroxyapatite

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