硬组织植入材料表/界面研究进展

doi:10.3724/SP.J.1077.2011.00001

无机材料学报 ›› 2011, Vol. 26 ›› Issue (1): 1-11.DOI: 10.3724/SP.J.1077.2011.00001

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硬组织植入材料表/界面研究进展

刘宣勇

(中国科学院上海硅酸盐研究所高性能陶瓷和超微结构国家重点实验室, 上海 200050)

收稿日期:2010-10-22 修回日期:2010-10-26 出版日期:2011-01-20 网络出版日期:2010-12-23
作者简介:刘宣勇, 男, 博士, 中国科学院上海硅酸盐研究所研究员、博士生导师, 主要从事生物医用材料表面改性方面的研究. 先后在生物材料领域著名期刊Biomaterials上发表论文18篇(第一作者7篇), 为著名科技期刊Materials Science & Engineering R- Reports撰写相关综述性论文2篇, 最高单篇论文SCI他引达220篇次, 并为CRC Press/Taylor & Francis Group等出版社主编/编著相关专著4部, 曾获上海市科技进步二等奖、中国机械工程学会青年科技成就奖、上海市新长征突击手标兵、中国科学院卢嘉锡青年人才奖及全国优秀博士学位论文奖.
基金资助:
上海市纳米专项(0952nm04400); 上海市国际科技合作基金项目(09520715200); 国家自然科学基金(51071168)

Progress in Research on the Surface/Interface of Materials for Hard Tissue Implant

LIU Xuan-Yong

(State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China)

Received:2010-10-22 Revised:2010-10-26 Published:2011-01-20 Online:2010-12-23
Supported by:
Shanghai Nano Science and Technology Special Project (0952nm04400); International Science and Technology Cooperation Fund of Shanghai (09520715200); National Nature Science Foundation of China (51071168)

摘要/Abstract

摘要： 硬组织植入材料表面和界面研究对改善和提高植入体性能及使用效果具有重要意义. 本文从硬组织植入体的发展规律着手, 综述了硬组织植入材料表面和界面研究的发展和趋势, 并着重探讨了目前临床应用最为广泛的硬组织材料体系?钛及其合金的表面改性技术和研究动态. 通过对钛及其合金进行表面改性, 提高其骨再生能力和抗菌性是近年来的研究热点. 表面负载生长因子和加涂生物活性涂层是提高钛合金植入体骨再生能力的常见手段, 装载抗菌药物和负载抗菌元素是改善钛合金植入体抗菌性能的有效方法. 随着纳米和生物技术的发展以及表面改性技术的革新, 通过复合表面改性获得兼具生物活性和抗菌性的钛合金植入体是硬组织植入体的重要发展方向.

关键词: 硬组织, 骨再生, 抗菌, 钛, 表/界面

Abstract: The investigation of the surface/interface of hard tissue implant materials is very important for improving their properties and application. This paper reviews the research progress and tendency of studies on the surface/interface for hard tissue implant, especially on titanium and titanium alloys, based on the law of hard tissue implant. The improvement of the bone regeneration and antibacterial properties of titanium-based alloys by surface modification has become the hot topics in recent years. Generally, loading growth factors and coating bioactive ceramics onto the surfaces of titanium and its alloys are valid ways to improve their ability of bone regeneration. And loading antibiotics and antibacterial agents have been proven to be an effective method to improve the antibacterial property of titanium implant. With the development of nanotechnology and biotechnology as well as the innovation of surface modification technologies, it is expected that to obtain titanium implants with combining bone regeneration and antibacterial properties by the hybrid surface modification.

Key words: hard tissue, bone regeneration, antibacterial, titanium, surface/interface

中图分类号:

R318

刘宣勇. 硬组织植入材料表/界面研究进展[J]. 无机材料学报, 2011, 26(1): 1-11.

LIU Xuan-Yong. Progress in Research on the Surface/Interface of Materials for Hard Tissue Implant[J]. Journal of Inorganic Materials, 2011, 26(1): 1-11.

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硬组织植入材料表/界面研究进展

Progress in Research on the Surface/Interface of Materials for Hard Tissue Implant

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