CaSiO3/TiO2复合生物陶瓷的制备与体外性能研究

doi:10.3724/SP.J.1077.2013.12138

摘要/Abstract

摘要：

CaSiO₃陶瓷作为潜在的生物材料受到广泛研究, 它生物活性好, 但化学稳定性、生物相容性、烧结以及力学性能不理想。本研究利用固相反应法分别将CaSiO₃与TiO₂以摩尔比2:1、3:1以及5:1进行混合, 在1100℃下煅烧制备了物相为β-CaSiO₃与CaTiSiO₅的CaSiO₃/TiO₂复合陶瓷。复合陶瓷的化学稳定性、常压下煅烧的致密度、力学性能比CaSiO₃陶瓷都得到了较大提升。随着CaSiO₃含量上升, 复合陶瓷力学性能及化学稳定性上升, 但在模拟体液中诱导磷灰石形成的能力明显下降。研究结果表明, CaSiO₃/TiO₂复合陶瓷是一种有应用潜力的骨修复材料, 且材料性能可通过改变组分实现调控以适应骨修复需要。

关键词: 含钛硅酸盐陶瓷, CaSiO₃, TiO₂, 磷灰石形成能力, 降解性

Abstract:

CaSiO₃ has attracted much attention as a bone substitute due to its strong ability to induce the formation of bonelike apatite in vitro. However, its poor chemical stability, biocompatibility, sintering and mechanical properties limit its further applications. In the present study, CaSiO₃/TiO₂ composites with initial CaSiO₃/TiO₂molar ratios at 2:1, 3:1 and 5:1 were prepared by solid-state reaction method. CaSiO₃/TiO₂ ceramics sintered at 1100℃ with the crystal phases of CaSiO₃ and CaTiSiO₅were found to have optimistic sintering behavior, mechanical properties and degradability compared with pure CaSiO₃ ceramics. With the CaSiO₃content increased, the mechanical properties were enhanced while the in vitro bioactivity and biodegradability decreased. All these results suggest that CaSiO₃/TiO₂ composite ceramics maybe a prospective candidate for bone repair and the properties can be adjusted by changing their chemical compositions to adapt to bone regeneration.

Key words: Ti-containing silicate ceramics, CaSiO₃, TiO₂, apatite formation ability, degradability

中图分类号:

TB332

虞慧娴, 宁聪琴. CaSiO₃/TiO₂复合生物陶瓷的制备与体外性能研究[J]. 无机材料学报, 2013, 28(1): 69-73.

YU Hui-Xian, NING Cong-Qin. Preparation and in vitro Properties of CaSiO₃/TiO₂ Composite Bioceramics[J]. Journal of Inorganic Materials, 2013, 28(1): 69-73.

图/表 7

图1 1100℃煅烧的CaSiO3/TiO2陶瓷XRD图谱

Fig. 1 XRD patterns of the CaSiO3/TiO2 ceramics sintered at 1100℃

Table 1 Porosity, bending strength and Young’s modulus of the β-CaSiO3/TiO2 ceramics sintered at 1100℃

Sample	Porosity/%	Bending strength /MPa	Young’s modulus /GPa
CTS^*	24±0.1	63±14.4	35±2.7
CS2T1	8±1.1	124±22.6	79±9.5
CS3T1	6±0.7	135±6.3	92±9.2
CS5T1	4±0.9	172±21.7	97±4.3
CS^*	12±0.1	109±4.9	53±4.1

图2 CaSiO3/TiO2陶瓷在SBF中浸泡14 d前后的电镜照片表2 CaSiO3/TiO2复合陶瓷浸泡SBF 14 d后表面P元素含量(EDS法检测)

Fig. 2 SEM images of the CaSiO3/TiO2 ceramics before and after soaking in SBF for 14 d

Table 2 P content of the CaSiO3/TiO2 composite ceramics after soaking in SBF for 14 d determined by EDS

Sample	P content/at%
CS2T1	0.21±0.03
CS3T1	0.20±0.05
CS5T1	0.16±0.02

图3 CaSiO3/TiO2陶瓷在Tris-HCl溶液中降解28 d失重率

Fig. 3 Weight loss results of the CaSiO3/TiO2 ceramics after soaking in Tris-HCl for 28 d

图4 β-CaSiO3/TiO2陶瓷在Tris-HCl浸泡28 d的Ca、Si、Ti离子释放

Fig. 4 Changes in element concentrations in the collected Tris-HCl

图5 β-CaSiO3/TiO2陶瓷在Tris-HCl浸泡14 d的pH值变化

Fig.5 Change in pH value of the collected Tris-HCl

参考文献 16

[1]	Sun J Y, Wei L, Liu X Y, et al. Influences of ionic dissolution products of dicalcium silicate coating on osteoblastic proliferation, differentiation and gene expression. Acta Biomater., 2009, 5(4): 1284-1293.
[2]	Kokubo T, Kushitani H, Sakka S, et al. Solutions able to reproduce invivo surface-structure changes in bioactive glass-ceramic A-W3. J. Biomed. Mater. Res., 1990, 24(6): 721-734.
[3]	Xue W C, Liu X Y, Zheng X B, et al. In vivo evaluation of plasma-sprayed wollastonite coating. Biomaterials, 2005, 26(17): 3455-3460.
[4]	Ni S Y, Chang J, Chou L, et al. Comparison of osteoblast-like cell responses to calcium silicate and tricalcium phosphate ceramics in vitro. J. Biomed. Mater. Res. B, 2007, 80B(1): 174-183.
[5]	Wu C, Chang J. Degradation, bioactivity, and cytocompatibility of diopside, akermanite, and bredigite ceramics. J. Biomed. Mater. Res. B, 2007, 83B(1): 153-160.
[6]	Wu C T, Ramaswamy Y, Soeparto A, et al. Incorporation of titanium into calcium silicate improved their chemical stability and biological properties. J. Biomed. Mater. Res. A, 2008, 86A(2): 402-410.
[7]	Wu C T, Ramaswamy Y, Kwik D, et al. The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties. Biomaterials, 2007, 28(21): 3171-3181.
[8]	Ramaswamy Y, Wu C, Van Hummel A, et al. The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic. Biomaterials, 2008, 29(33): 4392-4402.
[9]	Vrouwenvelder W C A, Groot C G, Degroot K. Better histology and biochemistry for osteoblasts cultured on titanium-doped bioactive glass: Bioglass 45S5 compared with iron-, titaniun-, fluorine- and boron-containing bioactive glasses. Biomaterials, 1994, 15(2): 97-106.
[10]	Harle J, Kim H W, Mordan N, et al. Initial responses of human osteoblasts to Sol-Gel modified titanium with hydroxyapatite and titania composition. Acta Biomater., 2006, 2(5): 547-556.
[11]	Fukuda C, Goto K, Imamura M, et al. Bioactive bone cement with a low content of titania particles without postsilanization: effect of filler content on osteoconductivity, mechanical properties, and handling characteristics. J. Biomed. Mater. Res. B, 2010, 95B(2): 407-413.
[12]	Long L H, Chen L D, Bai S Q, et al. Preparation of dense β-CaSiO3 ceramic with high mechanical strength and HAp formation ability in simulated body fluid. J. Eur. Ceram. Soc., 2006, 26(9): 1701-1706.
[13]	Yu H X, Ning C Q, Ding D Y. Synthesis and protein adsorption of calcium silicate/apatite composite powders. J. Biomater. Tissue Eng., 2012, 2(1): 76-82.
[14]	Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity?Biomaterials, 2006, 27(15): 2907-2915.
[15]	Hayakawa S, Tsuru K, Ohtsuki C, et al. Mechanism of apatite formation on a sodium silicate glass in a simulated body fluid. J. Am. Ceram. Soc., 1999, 82(8): 2155-2160.
[16]	Lu X, Leng Y. Theoretical analysis of calcium phosphate precipitation in simulated body fluid. Biomaterials, 2005, 26(10): 1097-1108.

CaSiO₃/TiO₂复合生物陶瓷的制备与体外性能研究

Preparation and in vitro Properties of CaSiO₃/TiO₂ Composite Bioceramics

RichHTML

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

图/表 7

参考文献 16

相关文章 15

编辑推荐

Metrics

本文评价

[1]	安琳, 吴淏, 韩鑫, 李耀刚, 王宏志, 张青红. 非贵金属Co_5.47N/N-rGO助催化剂增强TiO₂光催化制氢性能[J]. 无机材料学报, 2022, 37(5): 534-540.
[2]	吕庆洋, 张玉亭, 顾学红. 超声辅助溶胶-凝胶法制备中空纤维TiO₂超滤膜[J]. 无机材料学报, 2022, 37(10): 1051-1057.
[3]	肖翔, 郭少柯, 丁成, 张志洁, 黄海瑞, 徐家跃. CsPbBr₃@TiO₂核壳结构纳米复合材料用作水稳高效可见光催化剂[J]. 无机材料学报, 2021, 36(5): 507-512.
[4]	席文, 李海波. TiO₂/Ti₃C₂T_x复合材料的制备及其杂化电容脱盐特性的研究[J]. 无机材料学报, 2021, 36(3): 283-291.
[5]	刘彩, 刘芳, 黄方, 王晓娟. 海藻基CDs-Cu-TiO₂复合材料的制备及其光催化性能[J]. 无机材料学报, 2021, 36(11): 1154-1162.
[6]	李翠霞, 孙会珍, 金海泽, 史晓, 李文生, 孔文慧. 3D多级孔rGO/TiO₂复合材料的构筑及其光催化性能研究[J]. 无机材料学报, 2021, 36(10): 1039-1046.
[7]	王苹,李心宇,时占领,李海涛. Ag与Ag₂O协同增强TiO₂光催化制氢性能的研究[J]. 无机材料学报, 2020, 35(7): 781-788.
[8]	刘子阳, 耿振, 李朝阳. 牡蛎壳为原料制备医用CaCO₃/HA复合生物材料[J]. 无机材料学报, 2020, 35(5): 601-607.
[9]	季邦, 赵文锋, 段洁利, 马立哲, 付兰慧, 杨洲. 泡沫镍网负载TiO₂/WO₃薄膜对乙烯的光催化降解[J]. 无机材料学报, 2020, 35(5): 581-588.
[10]	王旭聪, 邓浩, 姜忠义, 袁立永. 不同N源无定形TiO₂/g-C₃N₄光催化还原Re(VII)性能[J]. 无机材料学报, 2020, 35(12): 1340-1348.
[11]	刘金云, 张玉亭, 洪周, 刘华, 王圣贤, 顾学红. 共挤出法制备双层中空纤维陶瓷复合膜[J]. 无机材料学报, 2020, 35(12): 1333-1339.
[12]	陈浩禹, 张亦文, 吴忠, 秦真波, 吴姗姗, 胡文彬. 强磁靶共溅射法制备具有室温磁电阻特性的Co-TiO₂纳米复合薄膜[J]. 无机材料学报, 2020, 35(11): 1263-1267.
[13]	吕喜庆, 张环宇, 李瑞, 张梅, 郭敏. Nb₂O₅包覆对TiO₂纳米阵列/上转换发光复合结构柔性染料敏化太阳能电池性能的影响[J]. 无机材料学报, 2019, 34(6): 590-598.
[14]	简刚, 刘美瑞, 张晨, 邵辉. 用于高介电复合材料的全包裹Ag@TiO₂填充颗粒的制备[J]. 无机材料学报, 2019, 34(6): 641-645.
[15]	强小虎,李彬彬,黄大建,周松毅. 氧化硼对聚磷酸钙纤维力学和降解性能的影响[J]. 无机材料学报, 2019, 34(2): 201-206.